Protective mechanisms of microRNA-27a against oxygen-glucose deprivation-induced injuries in hippocampal neurons
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چکیده
منابع مشابه
Protective mechanisms of microRNA-27a against oxygen-glucose deprivation-induced injuries in hippocampal neurons
Hypoxic injuries during fetal distress have been shown to cause reduced expression of microRNA-27a (miR-27a), which regulates sensitivity of cortical neurons to apoptosis. We hypothesized that miR-27a overexpression attenuates hypoxia- and ischemia-induced neuronal apoptosis by regulating FOXO1, an important transcription factor for regulating the oxidative stress response. miR-27a mimic was tr...
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Hypoxic-ischemic brain injury (HIBI) results in death or long-term neurologic impairment in both adults and children. In this study, we investigated the effects of microRNA-132 (miR-132) dysregulation on oxygen-glucose deprivation (OGD)-induced apoptosis in fetal rat hippocampal neurons, in order to reveal the therapeutic potential of miR-132 on HIBI. MiR-132 dysregulation was induced prior to ...
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The present study aimed to establish an oxygen‑glucose deprivation (OGD) model of ischemic and hypoxic cerebral neurons to investigate the protective effect of mild hypothermia on neuronal OGD and its mechanisms. OGD injury was significantly mitigated in cells with 24 h of mild hypothermia compared with cells without mild hypothermia; cell morphology improved, the lactic acid dehydrogenase (LDH...
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Brain ischemia is one common cerebrovascular disease with unfavorable prognosis and higher morbidity and mortality rates. The re-perfusion injury after primary ischemia further aggravated the progression of cerebral ischemia. The development of effective drugs for protecting neurons during brain ischemia-reperfusion damage is thus of critical importance. With pluripotent bioactivities, the prot...
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Brain ischemia leads to poor oxygen supply, and is one of the leading causes of brain damage and/or death. Neuroprotective agents are thus in great need for treatment purpose. Using both young and aged primary cultured hippocampal neurons as in vitro models, we investigated the effect of sodium hydrosulfide (NaHS), an exogenous donor of hydrogen sulfide, on oxygen-glucose deprivation (OGD) dama...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2016
ISSN: 1673-5374
DOI: 10.4103/1673-5374.189194